Validating a prognostic model

25 Sep

Development of bioactive materials for musculo-skeletal tissue repair, £676,251, Smith & Nephew UK Ltd High Performance Liquid Crystalline Bioresorbable Polymers, £877,765, Smith & Nephew UK Ltd Nanoscale Polymer Ceramic Composites for Biomedical Applications, £880,583, Smith & Nephew UK Limited Prototype Sensor for Periodontal disease monitoring, £385,969, Nanoforce Technology Limited Smart antibacterial coatings for Orthopaedic implants, £364,201, Smith & Nephew UK Ltd ALBio N – Artificial Ligament with Bioactive Nanostructure (OM-DTI Liga Mimeticc Proj), £751,622, Ti Genix Limited SMART-HIP: Smart Bioactive Nonocomposite Coatings for Enhanced Hip Replacement, £237,434, Tecvac Ltd CLASSAC, £328,032, PIPS TECHNOLOGY LTD Occu Tek, £344,278, HW Communications Ltd The Trusted Driver Model. degree in Biotechnology from Sahrdaya College of Engineering and Technology, Calicut University, Kerala. At IOB, she is working towards the integration and interpretation of phosphoproteomic data through visualization tools and curation of pathways. Patients and methods: A retrospective cohort of 381 HBV ACLF patients and a prospective cohort of 192 patients were included in this study.Independent predictors of disease progression were determined using univariate and multivariate Cox proportional hazard regression analysis, and a regression model for predicting prognosis was established.Results: Our model was constructed with five independent risk factors: hepatic encephalopathy, international normalized ratio, neutrophil–lymphocyte ratio, age, and total bilirubin, termed as the HINAT ACLF model, which showed the strongest predictive values compared with CLIF-C ACLF, CLIF-C Organ Failure, Sequential Organ Failure Assessment, CLIF-Sequential Organ Failure Assessment, Model for End-stage Liver Disease, Model for End-stage Liver Disease-sodium, and Child–Turcotte–Pugh scores; this model reduced the corresponding prediction error rates at 28 and 90 days by 16.4–54.5% after ACLF diagnosis in both the derivation cohort and the validation cohorts.Conclusion: The HINAT ACLF model can accurately predict the short-term mortality of patients with HBV ACLF as defined by Asia-Pacific Association for the Study of the Liver.

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It is clinically important to be able to identify individuals at risk for diabetes.

Total grant: £635,645,961 Average grant: £313,837 Smallest award: £9,600 – Mi Shorts (Excluding 2 grants with no information and a handful with a grant of £0) Biggest award: £9,811,222 – Congratulations Airbus UK You can see a full list of projects, amounts and recipients, Access the TSB Grant data set here.

Before you wade into that, the nosier readers of the blog will probably be interested in the salaries paid to the senior team that has also been released. TSB Technology Strategy Board Senior Salaries Nov 2010 We run conferences for people that build & invest in great tech businesses. Pelamis Full Scale Demonstration, £1,654,200, Ocean Power Delivery Ltd Novel Moored Tidal Stream Generating Equipment, £2,678,000, Atlantis Operations (UK) Limited Intercept, £663,321, Next Plc Demonstrator Component of Nanomaterials Characterisation, £170,371, Naneum Ltd RTT Tidal Stream Technology Development, £2,232,999, Lunar Energy Limited Project Neptune Phase 2 – Experimental Development, £2,058,410, SSE Generation Ltd Fabrication of complex 3-dimensional structures using direct writing and laser annealing., £531,349, Invotec Circuits Tamworth Limited Evaluating Downstream Processing Options at the Bioprocess-business interface, £381,721, Med Immune Limited Ro Chem Ox, £500,991, Alpha Environmental Systems Soil Mix Remediation Technology (SMi RT), £627,510, Bachy Soletanche Limited Secure Trace – Rapid and Accurate provenance confirmation for pharmaceutical products, £563,323, Authentix Crime Vis, £554,749, VISIMETRICS Carbon Dioxide Amine Seperation and Storage for Capture Ready PF Plant (CASS-Cap), £617,280, RWE Npower PLC The Modelling of an Impervious Nano-Composite Barrier System for Pipe Systems, £548,265, Wellstream International Limited TULIP, £955,895, GE Aviation Systems Ltd Stem Cells for Safer Medicine, £1,017,000, Stem Cells for Safer Medicine Application of Photometric Stereo in Dermatology (Photo Derm), £517,776, Biocompatibles VSAR: Viewers Situational & Spatial Awareness for Applied Risk & Reasoning, £1,550,767, Centre for Advanced Software Accelerated Process Excellence using Virtual Discrete Event Process Simulation, £543,052, De Monfort University The Use of Double Facades to Facilitate Demand Controlled Ventilation, £48,980, The Centre for Window Cladding Wireless Electricity Management Systems, £330,135, TWI limited Enzymatic synthesis of glucuronides, £383,022, Novacta Biosystems Limited Novel Inline Deposition System for High Performance CIGS Solar Cells, £306,417, Scientific Vacuum Systems Ltd Organic Photodetectors for Applications as Low-cost Sensors (OPALS), £571,201, Cambridge Display Technology Ltd Encapsulation technologies for advanced lighting systems (ENTALS), £435,573, Centre for Process Innovation Novel, environmentally friendly, compact diesel engine and vehicle cooling systems, £833,602, Caterpillar UK Limited Hydrogen Processed Magnet Scrap (Hy Pro MS)., £423,650, Powdermatri X Faraday Operated AWARE-NDT inspection of inaccessible electrical wiring in ageing aircraft, £675,732, TWI LTD Advanced Long Range Ultrasonic Technology (LRUT) for Integrity Assessment, £658,946, TWI Limited Measurement of Percentage Fatigue life using Non Destructive Techniques, £433,706, Rolls-Royce plc Recycling of Flexible Intermediate Bulk Containers into Self Reinforced Composites, £541,250, Woven PP Recycling Ltd Development of graphite/polymer nanocomposite material(Nano-Graph), £422,392, Wellstream International Limited Integrated Textile Solution for Ultraviolet Resistance of Airships and Related Craft, £839,762, Airborne Systems Durability of Polymers under Injection Conditons for Enhanced Oil Recovery, £402,326, MERL Ltd 3D Cell Based Assays with Physiological Relevance & Application in Drug Discovery, £446,437, Avanti Cell Science Ltd An Integrated System For Fab Bioproduction, £432,595, Polytherics Limited Biomanufacture of Hsp C Vaccines Against Bacterial Pathogens, £202,095, Immuno Biology Ltd Commercial Development of Tandem-Core based vaccines for Hepatitis, £551,489, i Qur Limited Heat Stabilization of Theraupetic Proteins In Biomanufacturing and Storage, £298,066, Arecor Limited The expression, modification and enhancement of protein therapeutics, £489,613, Glyco Form Ltd Novel Analytical Instrumentation to Detect Aggregation in Biopharmaceutical Processing, £292,643, Paraytec Ltd ORT-VAC: Live Bacterial Vectors for Vaccine Delivery, £605,209, Cobra Biomanufacturing Plc A Bioprocess Discovery Tool to Speed Up New Vaccine Development, £1,118,711, LGC Limited FOOTLITE, £1,537,396, MIRA Limited User Innovation, £231,000, ITO World Ltd User Innovation Plus, £397,137, University of the West of England, Bristol FREEFLOW, £2,627,822, Transport for London DEEP-Gen II – Completion of Techno-Economic Validation, £499,000, Tidal Generation Limited Enhanced Grid Connection Assessment Web Tool, £184,523, Econnect Ventures Ltd Suction Caisson Foundation for Offshore Meteorological Mast, £371,729, The Company 10k We Biomass Indirect Fired CHP System, £291,344, Talbotts Biomass Energy Systems Flex-diesel Engines with Sustainable Bio-fuels for Clean and Efficient On- and Off-Road Vehicles, £849,582, Jaguar Cars Limited Initial Research phase of momentum reversal lift turbine for tidal stream energy, £180,424, IT Power Ltd In-situ wireless monitoring of offshore wind towers and blades, £847,924, TWI Limited En Co Re – Ensuring Consent & Revocation, £2,514,133, Hewlett-Packard Limited Privacy Value Networks, £59,071, Consult Hyperion Ltd Visualisation & Other Methods of Expression, £66,558, Consult Hyperion Trust Economics, £1,263,271, Hewlett Packard Ltd ELLC Hybrid Displays for Automotive and Mobile Appliances, £254,368, Pelikon Ltd Printed High Voltage Inorganic Transistors (PHi VIT), £103,113, Pelikon Ltd High Quality Defect Minimised Film Surfaces, £631,483, Du Pont Teijin Films UK Ltd Novel Transparent Conducting Films and Their Use As An Alternative to ITO, £419,991, Epigem Limited Surface Conditioning of Plastic Electronics, £823,234, Cambridge Display Technology Ltd SOLFLEX-Low Temperature Sol-Gel Deposition of Novel Conductors on Flexible Plastics, £468,097, TWI Ltd Development of a low-cost manufacturing platform for high-throughput plastic electronics production, £630,596, Nano e Print Limited Nano Pore Bio Chip for the Point of Care Detection of Influenza, £524,075, Oxford Nanopore Technologies Creation of Non Volatile Organuic Memory RFID Tags, £226,760, Op Tek Limited FLEXOLED : Barriers for Flexible OLEDs using Atomic Layer Deposition, £224,141, Oxford Instruments Plasma Technology Limited Shape Formable Thin ACEL Devices, £250,442, Gwent Electronic Materials Limited Printable Organic Semiconducter Technology for Electronic Displays (POSTED), £1,253,119, Cambridge Display Technology Delivering Plastic Electronic Item Level Tracking for Perishable Goods, £771,500, Syngenta Ltd Nanocoated Plastic Films for Low Cost, Efficient, Hydrogen Production, £249,367, Microsharp Corporation Limited New Photo Detection Technology for Possible Use in Sensors for Homeland Security, £106,319, Symetrica Ltd Face Recognition At Intermediate distances, £237,302, Cybula Ltd.

This will be interesting reading if you want to consider applying as you can now see exactly what is funded, by company, by project, by date and by amount.

You can contact the TSB to see details of current grants here.